T cells are central to adaptive immunity, orchestrating targeted responses against infections and malignancies while forming a durable immunological memory. Memory T cells, particularly CD8+ subsets, ...

Investigators led by Navdeep Chandel, Ph.D., the David W. Cugell, MD, Professor of Medicine in the Division of Pulmonary and Critical Care, have discovered how the metabolism of mitochondria supports ...

For most people infected with Chikungunya virus (CHIKV), the illness is over in a few weeks, marked by a febrile illness, rash, and joint and muscle pain. But for as many as 60% of patients, the virus ...

Pre-wired ability in ‘resting’ T cells to remember past viral foes discovered, a promising breakthrough for targeted cancer therapies. A team of immunologists at the University of Massachusetts ...

The generation of durable CD8+ T cell memory following infection or vaccination is essential for protection against future encounters with the same or related pathogens. This process has traditionally ...

Uncover how memory T cells contribute to the recurrence of periodontal disease using cutting-edge immunology and single-cell technologies. This project explores how memory T cells contribute to the ...

The average human has about 1.8 trillion immune cells. These cells patrol the body for bacteria, viruses, cancers, and other ...

Findings from St. Jude Children's Research Hospital demonstrate that virtual memory T cells, a specialized group of immune cells, provide nonspecific immunity for infants early in life. The work stems ...

However, details of the intervening steps, as researchers have learned in the past 65 years, are quite complex — certain cells carry the flu antigen to the immune system, specific immune cells respond ...

Prostate cancer has long frustrated immunologists. Checkpoint inhibitors that unleash the immune system against tumors in the ...